PRP Versus PRF for Under Eyes What a 2026 Trial Found

What the research says about periorbital skin quality, limits, and planning sessions

If you are trying to decide between PRP vs PRF under eyes, the first helpful step is to name what you are actually trying to change. Many under eye concerns fall into two buckets: skin quality changes (for example how the skin looks and behaves), and structural hollowness (the contour of the tear trough area).

PRP and PRF are both autologous blood derived preparations that are used in periorbital rejuvenation. A recent randomized split face clinical trial compared PRP and PRF for periorbital skin quality over multiple sessions, tracking measures such as pigmentation, fine lines, mild hollowness, and patient satisfaction.

That distinction matters at consult. A treatment plan built for skin quality sets different expectations than a plan built for structural support, and the trial itself noted limits when hollowness is more severe.

What PRP and PRF are in under eye treatments

PRP (platelet rich plasma) and PRF (platelet rich fibrin) are both autologous, blood derived preparations used in regenerative aesthetic care. In practical terms, that means the material used in your treatment is prepared from your own blood.

In the under eye and periorbital area, these treatments are generally discussed in the context of periorbital skin quality. People tend to ask about them when their main goal is to look more refreshed, and when they want a plan that focuses on how the under eye skin looks, not only on volume.

If you are exploring regenerative options with Aesthetic Nurse Marta, you can see the clinic’s overview of these services on the PRP, PRF and plasma gel page.

What the clinical trial looked at, and what it found

One of the clearest pieces of patient relevant research in this space is a randomized split face clinical trial that compared PRP and PRF for periorbital skin quality over multiple sessions. Because it was split face, it was designed to compare PRP and PRF within the same person, rather than comparing different groups of people with different starting points.

Outcomes the trial tracked

The study tracked measures that map closely to what patients describe in a consult, including pigmentation, fine lines, mild hollowness, and patient satisfaction.

What improved, and what did not

The study reported improvement in both groups. It also noted limits for more severe hollowness. For someone trying to choose between PRP vs PRF under eyes, that “limit” comment is a key planning point: if the main issue is a deeper contour change, a regenerative approach aimed at skin quality may not match the result you have in mind.

Safety signals reported in the trial setting

In the trial setting, the authors reported no major adverse effects. That is reassuring, and it remains a narrow claim tied to this trial context, this setting, and the outcomes and events the study tracked.

How to use this information in a real consultation

A useful consult focuses less on picking a label and more on matching your goal to what the treatment is designed to affect. The trial’s tracked outcomes offer a practical way to structure that conversation.

If your goal is periorbital skin quality

If the biggest change you want is how the skin itself appears, the measures tracked in the study, including pigmentation and fine lines, are directly relevant to your decision. Bringing those exact words into your consultation helps you and your injector aim at a shared target.

If your goal is structural hollowness

If your main concern is the shape of the tear trough area, the trial’s note about limits for more severe hollowness is the point to take seriously. It is also where a full face assessment can matter, since under eye contour can be influenced by the surrounding support and proportions across the face.

For readers who want an under eye plan that is framed as an alternative approach in the tear trough conversation, Aesthetic Nurse Marta also offers Under-Eye Peptide Rejuvenation, which is positioned for under eye hollows, dark circles, and tired looking eyes.

Planning sessions and longevity without overpromising

The clinical trial described a protocol delivered over multiple sessions. That detail is the practical takeaway for booking: PRP and PRF under the eyes are generally planned as a series rather than a single appointment if your goal is periorbital rejuvenation focused on skin quality changes.

In consult, the decisions that most affect your experience usually sit in the plan details: how many sessions are being proposed, how they are spaced, and what the injector believes is realistic to change in your specific under eye anatomy. Aligning on that up front can prevent the most common kind of disappointment, which is not a complication, it is a goal mismatch.

For practical guidance on preparing and what recovery can look like after aesthetic treatments, use Patient information and care as your starting point, then confirm the details for your specific plan in person.

Questions to ask before you book PRP or PRF for under eyes

These questions keep the consult focused on the same outcomes the study tracked, and on the study’s stated limits.

• Which under eye concerns are you targeting in my case: pigmentation, fine lines, mild hollowness, or something else?
• Based on my anatomy, do you expect a skin quality change, a contour change, or both?
• How many sessions are you recommending, and what spacing are you planning?
• What does “limits for more severe hollowness” mean for my under eye area?
• What side effects or adverse effects should I watch for after a session, and when should I contact the clinic?

Choosing a qualified injector in Vaughan and the GTA

PRP vs PRF under eyes is a technical decision, and your safety and outcome depend on appropriate assessment, careful planning, and clear follow up. Aesthetic Nurse Marta is a nurse led clinic, and the consult is where you map your goals to what a regenerative under eye plan can reasonably target.

If you also want to understand who provides your care and how the clinic approaches aesthetic decision making, you can read more on About Marta Morozova.

The best way to choose between PRP and PRF for the under eye area is to anchor the decision to the outcomes that matter to you, then check whether your concern sits in skin quality changes, structural hollowness, or both. The split face trial reported improvement in both PRP and PRF groups for periorbital skin quality measures, and it highlighted limits when hollowness is more severe.

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